A porphyrin increases survival time of mice after intracerebral prion infection.
نویسندگان
چکیده
Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 2 شماره
صفحات -
تاریخ انتشار 2006